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KMID : 0380020060210010011
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Korean Journal of Biotechnology and Bioengineering
2006 Volume.21 No. 1 p.11 ~ p.15
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A Study on the Extraction and Efficacy of Bioactive Compound from Hovenia dulcis
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Kim Sung-Mun
Kang Sung-Hee
Ma Jin-Yeul
Kim Jin-Hyun
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Abstract
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The biological activities of extracts from the fruit, stem, and leaf of Hovenia dulcis were examined. In the batch mode of operation, the fruit, stem, and leaf of Hovenia dulcis were extracted with hot water for 10 hr. The fruit extract of Hovenia dulcis gave the highest activity for decreasing alcohol concentration which was 138% of control. The equilibrium between bioactive compound in the fruit (size : 4 mm) and hot water solution was reached within 6 hr and the recovery was 95% by three-times extraction. The fruit extract of Hovenia dulcis showed significant alcohol decrease in blood and hepatoprotective activity against -toxicity in rat. The fruit extract significantly inhibited the elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels.
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KEYWORD
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Hovenia dulcis, fruit extract, biological activity, alcohol concentration, hepatoprotective activity
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